Assay Detail
Functional
CHEMBL715068
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Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.21 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277985 | — | — | 1 | 7.51 |
| CHEMBL282787 | — | — | 1 | 7.28 |
| CHEMBL275237 | — | — | 1 | 6.75 |
| CHEMBL418527 | — | — | 1 | 6.00 |
| CHEMBL429036 | — | — | 1 | 5.90 |
| CHEMBL407052 | — | — | 1 | 5.84 |
| CHEMBL276704 | — | — | 1 | 5.51 |
| CHEMBL268605 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277985 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL282787 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL275237 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL418527 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL429036 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL407052 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL276704 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL268605 | — | IC50 | = | 11900.0 | nM | 4.92 |