Assay Detail
Functional
CHEMBL715093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of amonafide and azonafide with novel ring systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.43 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.16 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.14 |
| CHEMBL318380 | — | — | 1 | 7.10 |
| CHEMBL321274 | — | — | 1 | 6.96 |
| CHEMBL106541 | — | — | 1 | 6.89 |
| CHEMBL318355 | — | — | 1 | 6.77 |
| CHEMBL105650 | — | — | 1 | 6.64 |
| CHEMBL324189 | — | — | 1 | 6.54 |
| CHEMBL107783 | — | — | 1 | 6.54 |
| CHEMBL105797 | — | — | 1 | 6.54 |
| CHEMBL105615 | — | — | 1 | 6.51 |
| CHEMBL105801 | — | — | 1 | 6.50 |
| CHEMBL319702 | — | — | 1 | 6.40 |
| CHEMBL105266 | — | — | 1 | 6.30 |
| CHEMBL105503 | — | — | 1 | 6.25 |
| CHEMBL104820 | — | — | 1 | 6.23 |
| CHEMBL323455 | — | — | 1 | 6.21 |
| CHEMBL105443 | — | — | 1 | 6.17 |
| CHEMBL105035 | — | — | 1 | 6.09 |
| CHEMBL321071 | — | — | 1 | 6.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.93 |
| CHEMBL105277 | — | — | 1 | 5.89 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.75 |
| CHEMBL319187 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL318380 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL321274 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL106541 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL318355 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL105650 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL324189 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL107783 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL105797 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL105615 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL105801 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL319702 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL105266 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL105503 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL104820 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL323455 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL105443 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL105035 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL321071 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1172.0 | nM | 5.93 |
| CHEMBL105277 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL319187 | — | IC50 | = | 2000.0 | nM | 5.70 |