Assay Detail
Functional
CHEMBL715094
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Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of amonafide and azonafide with novel ring systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.69 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318380 | — | — | 1 | 7.72 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.55 |
| CHEMBL106541 | — | — | 1 | 7.40 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.39 |
| CHEMBL321274 | — | — | 1 | 6.89 |
| CHEMBL105650 | — | — | 1 | 6.82 |
| CHEMBL107783 | — | — | 1 | 6.82 |
| CHEMBL105797 | — | — | 1 | 6.82 |
| CHEMBL318355 | — | — | 1 | 6.75 |
| CHEMBL105801 | — | — | 1 | 6.64 |
| CHEMBL324189 | — | — | 1 | 6.57 |
| CHEMBL105266 | — | — | 1 | 6.55 |
| CHEMBL105615 | — | — | 1 | 6.51 |
| CHEMBL321071 | — | — | 1 | 6.50 |
| CHEMBL319702 | — | — | 1 | 6.50 |
| CHEMBL105503 | — | — | 1 | 6.47 |
| CHEMBL105443 | — | — | 1 | 6.41 |
| CHEMBL323455 | — | — | 1 | 6.36 |
| CHEMBL104820 | — | — | 1 | 6.26 |
| CHEMBL105035 | — | — | 1 | 6.05 |
| CHEMBL105277 | — | — | 1 | 6.00 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.92 |
| CHEMBL319187 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318380 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL106541 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL321274 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL105650 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL107783 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL105797 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL318355 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL105801 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL324189 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL105266 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL105615 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL321071 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL319702 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL105503 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL105443 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL323455 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL104820 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL105035 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL105277 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL319187 | — | IC50 | = | 1300.0 | nM | 5.89 |