Assay Detail
Functional
CHEMBL715113
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Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.19 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537254 | — | — | 1 | 10.30 |
| CHEMBL552569 | — | — | 1 | 10.00 |
| CHEMBL540775 | — | — | 1 | 9.72 |
| CHEMBL542329 | — | — | 1 | 9.55 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 9.40 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 9.31 |
| CHEMBL2137046 | — | — | 1 | 8.93 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537254 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL552569 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL540775 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL542329 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL2137046 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 481.0 | nM | 6.32 |