Assay Detail
Functional
CHEMBL715119
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Inhibitory activity against MCF7wt cell line using MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.56 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41700 | — | — | 1 | 7.30 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.12 |
| CHEMBL43453 | — | — | 1 | 6.82 |
| CHEMBL43229 | — | — | 1 | 6.57 |
| CHEMBL41526 | — | — | 1 | 6.57 |
| CHEMBL41863 | — | — | 1 | 5.78 |
| CHEMBL38451 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41700 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43 | AMSACRINE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL43453 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL43229 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL41526 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL41863 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL38451 | — | IC50 | = | 1670.0 | nM | 5.78 |