Assay Detail
Functional
CHEMBL715255
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Antagonist activity against mouse melanocortin-4 receptor (MC4R) using Schild analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel agouti-related-protein-based melanocortin-1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.49 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370694 | — | — | 1 | 6.98 |
| CHEMBL407346 | — | — | 1 | 6.81 |
| CHEMBL2370695 | — | — | 1 | 6.32 |
| CHEMBL2370696 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370694 | — | Kd | = | 104.71 | nM | 6.98 |
| CHEMBL407346 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL2370695 | — | Kd | = | 478.63 | nM | 6.32 |
| CHEMBL2370696 | — | Kd | = | 1445.44 | nM | 5.84 |