Assay Detail
Functional
CHEMBL715278
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Compound was evaluated for inhibition of tumor cell growth in MCF-7 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 8.15 |
| CHEMBL422395 | — | — | 1 | 6.10 |
| CHEMBL92234 | — | — | 1 | 4.66 |
| CHEMBL329619 | — | — | 1 | - |
| CHEMBL92589 | — | — | 1 | - |
| CHEMBL90795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL422395 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL92234 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL329619 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL92589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL90795 | — | IC50 | > | 100000.0 | nM | - |