Assay Detail
Binding
CHEMBL715425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activation of mouse recombinant Melanocortin-3 receptor.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.17 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.01 |
| CHEMBL386583 | — | — | 1 | 9.80 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.10 |
| CHEMBL264190 | — | — | 1 | 6.81 |
| CHEMBL317968 | — | — | 1 | 5.64 |
| CHEMBL330561 | — | — | 1 | 5.53 |
| CHEMBL94391 | — | — | 1 | 5.21 |
| CHEMBL330233 | — | — | 1 | 5.05 |
| CHEMBL432201 | — | — | 1 | 4.99 |
| CHEMBL96871 | — | — | 1 | 4.93 |
| CHEMBL327479 | — | — | 1 | 4.92 |
| CHEMBL94369 | — | — | 1 | 4.83 |
| CHEMBL320157 | — | — | 1 | 4.82 |
| CHEMBL431092 | — | — | 1 | 4.70 |
| CHEMBL329847 | — | — | 1 | - |
| CHEMBL432027 | — | — | 1 | - |
| CHEMBL275303 | — | — | 1 | - |
| CHEMBL329490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.098 | nM | 10.01 |
| CHEMBL386583 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL264190 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL317968 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL330561 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL94391 | — | EC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL330233 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL432201 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL96871 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL327479 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL94369 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL320157 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL431092 | — | EC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL329847 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL432027 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL275303 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL329490 | — | EC50 | > | 100000.0 | nM | - |