Assay Detail
Functional
CHEMBL715427
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Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.46 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.01 |
| CHEMBL430239 | MELATONAN | — | 1 | 9.80 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.10 |
| CHEMBL264190 | — | — | 1 | 6.81 |
| CHEMBL319871 | — | — | 1 | 5.69 |
| CHEMBL321870 | — | — | 1 | 5.39 |
| CHEMBL50056 | — | — | 1 | 5.36 |
| CHEMBL102688 | — | — | 2 | 5.11 |
| CHEMBL105113 | — | — | 1 | 4.47 |
| CHEMBL317228 | — | — | 1 | 4.36 |
| CHEMBL430843 | — | — | 1 | - |
| CHEMBL104052 | — | — | 1 | - |
| CHEMBL430489 | — | — | 1 | - |
| CHEMBL322889 | — | — | 1 | - |
| CHEMBL432018 | — | — | 1 | - |
| CHEMBL104397 | — | — | 1 | - |
| CHEMBL319922 | — | — | 1 | - |
| CHEMBL421028 | — | — | 1 | - |
| CHEMBL106959 | — | — | 1 | - |
| CHEMBL317210 | — | — | 1 | - |
| CHEMBL318119 | — | — | 1 | - |
| CHEMBL607103 | — | — | 1 | - |
| CHEMBL607104 | — | — | 1 | - |
| CHEMBL431242 | — | — | 1 | - |
| CHEMBL102391 | — | — | 1 | - |
| CHEMBL104010 | — | — | 1 | - |
| CHEMBL104880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.098 | nM | 10.01 |
| CHEMBL430239 | MELATONAN | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL264190 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL319871 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL321870 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL50056 | — | EC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL102688 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL102688 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL105113 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL317228 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL430843 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL430489 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL322889 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL432018 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL104052 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL104397 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL319922 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL421028 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL106959 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL317210 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL318119 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL607103 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL607104 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL431242 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL102391 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL104010 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL104880 | — | EC50 | > | 100000.0 | nM | - |