Assay Detail
Functional
CHEMBL715575
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Antagonistic activity against metabotropic glutamate receptor 1 (mGluR1) was evaluated
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.72 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420262 | — | — | 1 | 5.24 |
| CHEMBL432038 | — | — | 1 | 5.11 |
| CHEMBL329920 | — | — | 1 | 4.75 |
| CHEMBL319732 | — | — | 1 | 4.26 |
| CHEMBL95868 | — | — | 1 | 4.24 |
| CHEMBL97574 | — | — | 1 | - |
| CHEMBL319279 | — | — | 1 | - |
| CHEMBL439775 | — | — | 1 | - |
| CHEMBL99462 | — | — | 1 | - |
| CHEMBL97200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420262 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL432038 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL329920 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL319732 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL95868 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL97574 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL439775 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL97200 | — | IC50 | > | 100000.0 | nM | - |