Assay Detail
Functional
CHEMBL715578
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Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 3 (CHEMBL3067) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.04 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 7.80 |
| CHEMBL95868 | — | — | 1 | 7.54 |
| CHEMBL97200 | — | — | 1 | 7.40 |
| CHEMBL439775 | — | — | 1 | 7.12 |
| CHEMBL329920 | — | — | 1 | 7.00 |
| CHEMBL319732 | — | — | 1 | 6.91 |
| CHEMBL319279 | — | — | 1 | 6.90 |
| CHEMBL99462 | — | — | 1 | 6.71 |
| CHEMBL97574 | — | — | 1 | 6.00 |
| CHEMBL420262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL95868 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL97200 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL439775 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL329920 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL319732 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL319279 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL99462 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL97574 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL420262 | — | IC50 | > | 1000.0 | nM | - |