Assay Detail
Binding
CHEMBL715688
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Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.07 |
| CHEMBL2115441 | — | — | 1 | 7.61 |
| CHEMBL430239 | MELATONAN | — | 1 | 7.36 |
| CHEMBL3350396 | — | — | 1 | 6.85 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 6.25 |
| CHEMBL410217 | — | — | 1 | - |
| CHEMBL217584 | — | — | 1 | - |
| CHEMBL413260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL2115441 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL430239 | MELATONAN | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL3350396 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL214332 | INTERMEDINE | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL410217 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL217584 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL413260 | — | IC50 | > | 1000.0 | nM | - |