Assay Detail
Functional
CHEMBL715726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88612 | — | — | 1 | 6.54 |
| CHEMBL88553 | — | — | 1 | 6.43 |
| CHEMBL94631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88612 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL88553 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL94631 | — | IC50 | > | 100000.0 | nM | - |