Assay Detail
Binding
CHEMBL715751
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Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.58 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.46 |
| CHEMBL2115165 | — | — | 1 | 7.92 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.85 |
| CHEMBL261932 | TANOMASTAT | 2.0 | 1 | 6.87 |
| CHEMBL76222 | REBIMASTAT | 2.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2115165 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL261932 | TANOMASTAT | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL76222 | REBIMASTAT | IC50 | = | 157.0 | nM | 6.80 |