Assay Detail
Binding
CHEMBL715830
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In vitro inhibitory activity against matrix metalloprotease-2
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.32 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311004 | — | — | 1 | 9.40 |
| CHEMBL82169 | — | — | 1 | 9.30 |
| CHEMBL315114 | — | — | 1 | 9.22 |
| CHEMBL311266 | — | — | 2 | 9.10 |
| CHEMBL312100 | — | — | 1 | 9.05 |
| CHEMBL85374 | — | — | 1 | 9.00 |
| CHEMBL83955 | — | — | 1 | 9.00 |
| CHEMBL83282 | — | — | 1 | 8.96 |
| CHEMBL311097 | — | — | 1 | 8.55 |
| CHEMBL79267 | — | — | 1 | 8.49 |
| CHEMBL44383 | — | — | 1 | 8.18 |
| CHEMBL402745 | — | — | 1 | 8.14 |
| CHEMBL10454 | — | — | 1 | 7.90 |
| CHEMBL313340 | — | — | 1 | 7.62 |
| CHEMBL79906 | — | — | 1 | 7.28 |
| CHEMBL82113 | — | — | 1 | 7.24 |
| CHEMBL83616 | — | — | 1 | 7.04 |
| CHEMBL85026 | — | — | 1 | 6.26 |
| CHEMBL253680 | — | — | 1 | - |
| CHEMBL83368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311004 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL82169 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL315114 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL311266 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL312100 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL85374 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL83955 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL83282 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL311097 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL79267 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL44383 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL402745 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL10454 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL313340 | — | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL79906 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL82113 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL83616 | — | IC50 | = | 91.3 | nM | 7.04 |
| CHEMBL85026 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL311266 | — | IC50 | < | 0.4 | nM | - |
| CHEMBL253680 | — | IC50 | < | 0.4 | nM | - |
| CHEMBL83368 | — | IC50 | < | 0.4 | nM | - |