Assay Detail
Binding
CHEMBL715833
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Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.50 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155923 | — | — | 1 | 8.89 |
| CHEMBL432882 | — | — | 1 | 8.70 |
| CHEMBL155874 | — | — | 1 | 8.59 |
| CHEMBL157704 | — | — | 1 | 8.19 |
| CHEMBL160232 | — | — | 1 | 8.17 |
| CHEMBL346265 | — | — | 1 | 8.08 |
| CHEMBL345200 | — | — | 1 | 8.00 |
| CHEMBL160305 | — | — | 1 | 8.00 |
| CHEMBL347138 | — | — | 1 | 7.89 |
| CHEMBL160153 | — | — | 1 | 7.89 |
| CHEMBL346118 | — | — | 1 | 7.77 |
| CHEMBL345597 | — | — | 1 | 7.72 |
| CHEMBL297792 | S-3304 | 1.0 | 1 | 7.70 |
| CHEMBL440921 | — | — | 1 | 7.64 |
| CHEMBL160969 | — | — | 1 | 7.47 |
| CHEMBL159229 | — | — | 1 | 7.30 |
| CHEMBL157705 | — | — | 1 | 7.30 |
| CHEMBL157363 | — | — | 1 | 7.30 |
| CHEMBL155959 | — | — | 1 | 7.30 |
| CHEMBL351363 | — | — | 1 | 7.28 |
| CHEMBL298699 | — | — | 1 | 7.28 |
| CHEMBL160940 | — | — | 1 | 7.18 |
| CHEMBL350674 | — | — | 1 | 7.08 |
| CHEMBL347658 | — | — | 1 | 6.96 |
| CHEMBL288750 | — | — | 1 | 6.89 |
| CHEMBL347847 | — | — | 1 | 6.55 |
| CHEMBL49411 | — | — | 1 | 6.51 |
| CHEMBL349798 | — | — | 1 | 6.00 |
| CHEMBL155815 | — | — | 1 | 6.00 |
| CHEMBL160712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155923 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL432882 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL155874 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL157704 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL160232 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL346265 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL345200 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL160305 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL347138 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL160153 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL346118 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL345597 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL297792 | S-3304 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL440921 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL160969 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL159229 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL155959 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL157363 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL157705 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL351363 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL298699 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL160940 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL350674 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL347658 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL288750 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL347847 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL49411 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL349798 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL155815 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL348129 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL158798 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL160667 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL159013 | — | IC50 | < | 40.0 | nM | - |
| CHEMBL351110 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL160465 | — | IC50 | < | 40.0 | nM | - |
| CHEMBL157289 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL348088 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL49671 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL345238 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL160245 | — | IC50 | < | 40.0 | nM | - |
| CHEMBL158674 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL291194 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL347612 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL348335 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL157243 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL155848 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL157592 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL160712 | — | IC50 | > | 1000.0 | nM | - |