Assay Detail
Binding
CHEMBL715834
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Inhibition of human matrix metalloprotease-2 (MMP-2)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.74 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.14 |
| CHEMBL45483 | — | — | 1 | 8.22 |
| CHEMBL326489 | — | — | 1 | 6.12 |
| CHEMBL117225 | — | — | 1 | 5.75 |
| CHEMBL115460 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL45483 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL326489 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL117225 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL115460 | — | IC50 | = | 34200.0 | nM | 4.47 |