Assay Detail
Binding
CHEMBL715837
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Inhibitory activity against matrix metalloprotease-2 (MMP-2) in quenched fluorescence assay at pH 7.4
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.27 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10671 | — | — | 1 | 8.22 |
| CHEMBL10761 | — | — | 1 | 8.22 |
| CHEMBL10673 | — | — | 1 | 8.22 |
| CHEMBL276016 | — | — | 1 | 8.10 |
| CHEMBL10848 | — | — | 1 | 8.10 |
| CHEMBL10674 | — | — | 1 | 8.10 |
| CHEMBL10908 | — | — | 1 | 8.05 |
| CHEMBL10257 | — | — | 1 | 8.05 |
| CHEMBL275700 | — | — | 1 | 8.05 |
| CHEMBL10296 | — | — | 1 | 7.92 |
| CHEMBL10454 | — | — | 1 | 7.92 |
| CHEMBL10655 | — | — | 1 | 7.80 |
| CHEMBL10809 | — | — | 1 | 7.77 |
| CHEMBL10180 | — | — | 1 | 7.72 |
| CHEMBL10672 | — | — | 1 | 7.70 |
| CHEMBL274881 | — | — | 1 | 7.70 |
| CHEMBL10952 | — | — | 1 | 7.64 |
| CHEMBL10335 | — | — | 1 | 7.62 |
| CHEMBL275130 | — | — | 1 | 7.58 |
| CHEMBL10431 | — | — | 1 | 7.55 |
| CHEMBL10881 | — | — | 1 | 7.54 |
| CHEMBL11188 | — | — | 1 | 7.54 |
| CHEMBL10935 | — | — | 1 | 7.51 |
| CHEMBL10953 | — | — | 1 | 7.48 |
| CHEMBL10266 | — | — | 1 | 7.48 |
| CHEMBL10590 | — | — | 1 | 7.34 |
| CHEMBL274174 | — | — | 1 | 7.06 |
| CHEMBL10646 | — | — | 1 | 7.00 |
| CHEMBL10806 | — | — | 1 | 6.98 |
| CHEMBL10792 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10671 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL10673 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL10761 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL276016 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL10848 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL10674 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL10908 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL10257 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL275700 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL10296 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL10454 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL10655 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL10809 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL10180 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL274881 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL10672 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL10952 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL10335 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL275130 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL10431 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL10881 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL11188 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL10935 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL10266 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL10953 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL10590 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL274174 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL10646 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL10806 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL10792 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL10469 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL11005 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL275754 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL10851 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL268050 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL10492 | — | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL275345 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL10822 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL10760 | — | IC50 | = | 1475.0 | nM | 5.83 |
| CHEMBL417977 | — | IC50 | = | 2391.0 | nM | 5.62 |
| CHEMBL10193 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL407640 | — | IC50 | - | nM | - | |
| CHEMBL10885 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL274997 | — | IC50 | > | 10000.0 | nM | - |