Assay Detail
Binding
CHEMBL715838
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Inhibition of Matrix metalloprotease-2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.36 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317132 | — | — | 1 | 10.00 |
| CHEMBL317508 | — | — | 1 | 9.40 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.30 |
| CHEMBL323371 | — | — | 1 | 9.30 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.74 |
| CHEMBL101121 | — | — | 1 | 8.52 |
| CHEMBL102459 | — | — | 1 | 8.22 |
| CHEMBL103442 | — | — | 1 | 8.15 |
| CHEMBL100805 | — | — | 1 | 7.62 |
| CHEMBL100584 | — | — | 1 | 7.60 |
| CHEMBL323148 | — | — | 1 | 7.44 |
| CHEMBL38851 | — | — | 1 | 7.31 |
| CHEMBL318795 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317132 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL317508 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL323371 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL101121 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL102459 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL103442 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL100805 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL100584 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL323148 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL38851 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL318795 | — | IC50 | = | 82.0 | nM | 7.09 |