Assay Detail
Binding
CHEMBL715839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Matrix metalloprotease-2
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.55 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94248 | — | — | 1 | 9.70 |
| CHEMBL92899 | — | — | 3 | 9.70 |
| CHEMBL93231 | — | — | 1 | 9.70 |
| CHEMBL91124 | — | — | 1 | 9.70 |
| CHEMBL92778 | — | — | 1 | 9.40 |
| CHEMBL92923 | — | — | 1 | 9.30 |
| CHEMBL91434 | — | — | 1 | 9.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.12 |
| CHEMBL433171 | — | — | 1 | 8.89 |
| CHEMBL90211 | — | — | 1 | 8.89 |
| CHEMBL90762 | — | — | 1 | 8.49 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.34 |
| CHEMBL328346 | — | — | 1 | 8.30 |
| CHEMBL92327 | — | — | 1 | 7.40 |
| CHEMBL90487 | — | — | 1 | 7.10 |
| CHEMBL419315 | — | — | 1 | 6.74 |
| CHEMBL329659 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94248 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL93231 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL92899 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL91124 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL92778 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL92923 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL91434 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL90211 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL433171 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL90762 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL328346 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL92899 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL92327 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL90487 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL419315 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL329659 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL92899 | — | IC50 | < | 0.1 | nM | - |