Assay Detail
Binding
CHEMBL715840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Matrix metalloprotease-2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heterocycle-based MMP inhibitors with P2' substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.67 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427616 | — | — | 1 | 9.30 |
| CHEMBL415482 | — | — | 1 | 9.17 |
| CHEMBL269019 | — | — | 1 | 9.15 |
| CHEMBL7108 | — | — | 1 | 9.00 |
| CHEMBL7390 | — | — | 1 | 9.00 |
| CHEMBL267939 | — | — | 1 | 8.80 |
| CHEMBL7756 | — | — | 1 | 8.62 |
| CHEMBL268114 | — | — | 1 | 8.57 |
| CHEMBL266292 | — | — | 1 | 8.47 |
| CHEMBL6572 | — | — | 1 | 8.28 |
| CHEMBL268377 | — | — | 1 | 8.28 |
| CHEMBL6973 | — | — | 1 | 8.06 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427616 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL415482 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL269019 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL7108 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL7390 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL267939 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL7756 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL268114 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL266292 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL6572 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL268377 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL6973 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 9.1 | nM | 8.04 |