Assay Detail
Binding
CHEMBL715843
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Inhibition of human matrix metalloprotease-2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
MMPs inhibitors: new succinylhydroxamates with selective inhibition of MMP-2 over MMP-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.61 | 9.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 9.98 |
| CHEMBL95237 | — | — | 1 | 8.89 |
| CHEMBL420259 | — | — | 1 | 8.24 |
| CHEMBL318902 | — | — | 1 | 8.22 |
| CHEMBL2111573 | — | — | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 0.104 | nM | 9.98 |
| CHEMBL95237 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL420259 | — | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL318902 | — | IC50 | = | 5.97 | nM | 8.22 |
| CHEMBL2111573 | — | IC50 | = | 19.6 | nM | 7.71 |