Assay Detail
Binding
CHEMBL715847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of selective MMP inhibitors with an aryl backbone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.57 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.52 |
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 9.40 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.12 |
| CHEMBL83209 | — | — | 1 | 8.89 |
| CHEMBL310008 | — | — | 1 | 8.70 |
| CHEMBL309465 | — | — | 1 | 8.48 |
| CHEMBL94467 | — | — | 1 | 7.46 |
| CHEMBL94872 | — | — | 1 | 7.16 |
| CHEMBL319055 | — | — | 1 | 6.83 |
| CHEMBL433415 | — | — | 1 | 6.00 |
| CHEMBL330078 | — | — | 1 | 5.75 |
| CHEMBL97478 | — | — | 1 | 5.64 |
| CHEMBL94324 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL440498 | CTS-1027 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL83209 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL310008 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL309465 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL94467 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL94872 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL319055 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL433415 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL330078 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL97478 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL94324 | — | IC50 | = | 3500.0 | nM | 5.46 |