Assay Detail
Binding
CHEMBL715849
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In vitro inhibition of human Matrix metalloprotease-2.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.64 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40151 | — | — | 1 | 9.00 |
| CHEMBL416421 | — | — | 1 | 8.40 |
| CHEMBL41408 | — | — | 1 | 8.40 |
| CHEMBL40143 | — | — | 1 | 8.40 |
| CHEMBL38868 | — | — | 1 | 8.40 |
| CHEMBL43411 | — | — | 1 | 8.22 |
| CHEMBL41102 | — | — | 1 | 8.10 |
| CHEMBL42970 | — | — | 1 | 7.80 |
| CHEMBL39566 | — | — | 1 | 7.70 |
| CHEMBL41324 | — | — | 1 | 7.70 |
| CHEMBL39601 | — | — | 1 | 7.58 |
| CHEMBL285296 | — | — | 1 | 7.32 |
| CHEMBL288067 | — | — | 1 | 7.24 |
| CHEMBL38299 | — | — | 1 | 7.21 |
| CHEMBL40613 | — | — | 1 | 7.07 |
| CHEMBL288385 | — | — | 1 | 7.05 |
| CHEMBL40335 | — | — | 1 | 6.89 |
| CHEMBL41943 | — | — | 1 | 6.75 |
| CHEMBL39921 | — | — | 1 | 5.89 |
| CHEMBL418437 | — | — | 1 | - |
| CHEMBL41150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40151 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL416421 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL41408 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL40143 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL38868 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL43411 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL41102 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL42970 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL39566 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL41324 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39601 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL285296 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL288067 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL38299 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL40613 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL288385 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL40335 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL41943 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL39921 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL418437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL41150 | — | IC50 | > | 10000.0 | nM | - |