Assay Detail
Binding
CHEMBL715873
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Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.84 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425316 | — | — | 1 | 9.30 |
| CHEMBL355797 | — | — | 1 | 9.28 |
| CHEMBL172249 | — | — | 1 | 8.69 |
| CHEMBL173846 | — | — | 1 | 8.61 |
| CHEMBL170315 | — | — | 1 | 8.53 |
| CHEMBL539171 | — | — | 1 | 8.36 |
| CHEMBL173686 | — | — | 1 | 8.31 |
| CHEMBL170429 | — | — | 1 | 8.29 |
| CHEMBL366478 | — | — | 1 | 8.28 |
| CHEMBL173316 | — | — | 1 | 8.28 |
| CHEMBL368857 | — | — | 1 | 8.27 |
| CHEMBL173027 | — | — | 1 | 8.19 |
| CHEMBL174315 | — | — | 1 | 8.09 |
| CHEMBL177072 | — | — | 1 | 7.97 |
| CHEMBL175164 | — | — | 1 | 7.94 |
| CHEMBL171962 | — | — | 1 | 7.91 |
| CHEMBL173754 | — | — | 1 | 7.89 |
| CHEMBL173235 | — | — | 1 | 7.83 |
| CHEMBL368205 | — | — | 1 | 7.62 |
| CHEMBL173744 | — | — | 1 | 7.61 |
| CHEMBL172722 | — | — | 1 | 7.53 |
| CHEMBL353536 | — | — | 1 | 7.53 |
| CHEMBL172548 | — | — | 1 | 7.46 |
| CHEMBL173326 | — | — | 1 | 7.32 |
| CHEMBL172415 | — | — | 1 | 7.29 |
| CHEMBL172885 | — | — | 1 | 7.19 |
| CHEMBL367710 | — | — | 1 | 7.17 |
| CHEMBL172886 | — | — | 1 | 7.14 |
| CHEMBL171292 | — | — | 1 | 7.08 |
| CHEMBL436049 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425316 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL355797 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL172249 | — | Ki | = | 2.04 | nM | 8.69 |
| CHEMBL173846 | — | Ki | = | 2.43 | nM | 8.61 |
| CHEMBL170315 | — | Ki | = | 2.95 | nM | 8.53 |
| CHEMBL539171 | — | Ki | = | 4.36 | nM | 8.36 |
| CHEMBL173686 | — | Ki | = | 4.85 | nM | 8.31 |
| CHEMBL170429 | — | Ki | = | 5.19 | nM | 8.29 |
| CHEMBL366478 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL173316 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL368857 | — | Ki | = | 5.43 | nM | 8.27 |
| CHEMBL173027 | — | Ki | = | 6.41 | nM | 8.19 |
| CHEMBL174315 | — | Ki | = | 8.15 | nM | 8.09 |
| CHEMBL177072 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL175164 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL171962 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL173754 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL173235 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL368205 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL173744 | — | Ki | = | 24.4 | nM | 7.61 |
| CHEMBL172722 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL353536 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL172548 | — | Ki | = | 34.9 | nM | 7.46 |
| CHEMBL173326 | — | Ki | = | 47.8 | nM | 7.32 |
| CHEMBL172415 | — | Ki | = | 51.4 | nM | 7.29 |
| CHEMBL172885 | — | Ki | = | 64.4 | nM | 7.19 |
| CHEMBL367710 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL172886 | — | Ki | = | 72.9 | nM | 7.14 |
| CHEMBL171292 | — | Ki | = | 82.4 | nM | 7.08 |
| CHEMBL436049 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL171986 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL172181 | — | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL433981 | — | Ki | > | 650.0 | nM | - |
| CHEMBL418655 | — | Ki | > | 650.0 | nM | - |
| CHEMBL174014 | — | Ki | > | 650.0 | nM | - |