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Assay Detail

CHEMBL715875

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of matrix metalloprotease-3 (MMP-3).
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Stromelysin-1 (CHEMBL283)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protease inhibitors: current status and future prospects.
Leung D, Abbenante G, Fairlie DP.
J Med Chem (2000) 43 : 305 -341
PubMed 10669559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.49 9.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL75094 PRINOMASTAT 3.0 1 9.57
CHEMBL440498 CTS-1027 2.0 1 8.03
CHEMBL114673 1 7.75
CHEMBL115727 1 7.75
CHEMBL114944 1 7.52
CHEMBL514138 CGS-27023A 1 7.37
CHEMBL261932 TANOMASTAT 2.0 1 6.84
CHEMBL114116 1 6.30
CHEMBL115653 CIPEMASTAT 2.0 1 6.28
CHEMBL23725 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL75094 PRINOMASTAT Ki = 0.27 nM 9.57
CHEMBL440498 CTS-1027 Ki = 9.3 nM 8.03
CHEMBL114673 Ki = 18.0 nM 7.75
CHEMBL115727 Ki = 18.0 nM 7.75
CHEMBL114944 Ki = 30.0 nM 7.52
CHEMBL514138 CGS-27023A Ki = 43.0 nM 7.37
CHEMBL261932 TANOMASTAT Ki = 143.0 nM 6.84
CHEMBL114116 Ki = 500.0 nM 6.30
CHEMBL115653 CIPEMASTAT Ki = 527.0 nM 6.28
CHEMBL23725 Ki < 1.0 nM -