Assay Detail
Functional
CHEMBL715935
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Inhibition of MTX uptake in MOLT-4 human T-cell leukemia cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.03 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355616 | — | — | 1 | 9.70 |
| CHEMBL169896 | OSI-7904 | 2.0 | 1 | 9.52 |
| CHEMBL167164 | — | — | 1 | 9.12 |
| CHEMBL355323 | — | — | 1 | 9.07 |
| CHEMBL169506 | — | — | 1 | 8.47 |
| CHEMBL324739 | — | — | 1 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355616 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL169896 | OSI-7904 | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL167164 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL355323 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL169506 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL324739 | — | Ki | = | 4.9 | nM | 8.31 |