Assay Detail
Functional
CHEMBL715936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MTX uptake in MOLT-4 human T-cell leukemia cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.64 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168367 | — | — | 1 | 9.30 |
| CHEMBL168907 | — | — | 1 | 8.74 |
| CHEMBL355662 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168367 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL168907 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL355662 | — | Ki | = | 13.0 | nM | 7.89 |