Assay Detail
Binding
CHEMBL716347
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Inhibitory activity against mouse melanocortin 1 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.52 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348530 | — | — | 1 | 10.22 |
| CHEMBL338768 | — | — | 1 | 6.82 |
| CHEMBL337940 | — | — | 1 | - |
| CHEMBL125492 | — | — | 1 | - |
| CHEMBL338766 | — | — | 1 | - |
| CHEMBL123744 | — | — | 1 | - |
| CHEMBL125819 | — | — | 1 | - |
| CHEMBL332442 | — | — | 1 | - |
| CHEMBL338747 | — | — | 1 | - |
| CHEMBL332443 | — | — | 1 | - |
| CHEMBL127861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348530 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL338768 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL337940 | — | IC50 | > | 1800.0 | nM | - |
| CHEMBL125492 | — | IC50 | > | 1600.0 | nM | - |
| CHEMBL338766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123744 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL125819 | — | IC50 | > | 600.0 | nM | - |
| CHEMBL332442 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338747 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL332443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL127861 | — | IC50 | > | 1400.0 | nM | - |