Assay Detail
Binding
CHEMBL716474
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Effective concentration for the effect of Melanocortin 1 receptor in the frog skin.
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | frog |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.52 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350330 | — | — | 1 | 10.22 |
| CHEMBL430239 | MELATONAN | — | 2 | 10.00 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 10.00 |
| CHEMBL2370906 | — | — | 1 | 9.52 |
| CHEMBL2364555 | — | — | 1 | 9.36 |
| CHEMBL2364550 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350330 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL430239 | MELATONAN | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL430239 | MELATONAN | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2370906 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2364555 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL2364550 | — | EC50 | = | 28.6 | nM | 7.54 |