Assay Detail
Functional
CHEMBL716490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.98 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.72 |
| CHEMBL263948 | — | — | 1 | 9.72 |
| CHEMBL264190 | — | — | 1 | 6.64 |
| CHEMBL302703 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL263948 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL264190 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL302703 | — | EC50 | = | 1428.0 | nM | 5.84 |