Assay Detail
Binding
CHEMBL716497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptor
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.84 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 2 | 9.40 |
| CHEMBL2364555 | — | — | 1 | 9.30 |
| CHEMBL2370906 | — | — | 1 | 8.70 |
| CHEMBL3350330 | — | — | 1 | 8.52 |
| CHEMBL2364550 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL430239 | MELATONAN | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2364555 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2370906 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3350330 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2364550 | — | IC50 | = | 15.0 | nM | 7.82 |