Assay Detail
Binding
CHEMBL716608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Matrix metalloprotease-2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.31 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 9.40 |
| CHEMBL50209 | — | — | 1 | 7.70 |
| CHEMBL52107 | — | — | 1 | 7.52 |
| CHEMBL300902 | — | — | 1 | 7.30 |
| CHEMBL52116 | — | — | 1 | 6.75 |
| CHEMBL295950 | — | — | 1 | 6.27 |
| CHEMBL51996 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL50209 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL52107 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL300902 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL52116 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL295950 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL51996 | — | IC50 | = | 550.0 | nM | 6.26 |