Assay Detail
Binding
CHEMBL716609
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In vitro inhibition of human matrix metalloprotease-2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.40 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323090 | — | — | 1 | 9.52 |
| CHEMBL105311 | — | — | 1 | 9.40 |
| CHEMBL102798 | — | — | 1 | 9.15 |
| CHEMBL104022 | — | — | 1 | 9.15 |
| CHEMBL102438 | — | — | 1 | 9.15 |
| CHEMBL102785 | — | — | 1 | 9.00 |
| CHEMBL421029 | — | — | 1 | 8.92 |
| CHEMBL106016 | — | — | 1 | 8.92 |
| CHEMBL407443 | — | — | 1 | 8.80 |
| CHEMBL104599 | — | — | 1 | 8.80 |
| CHEMBL420656 | — | — | 1 | 8.64 |
| CHEMBL320442 | — | — | 1 | 8.49 |
| CHEMBL105279 | — | — | 1 | 8.42 |
| CHEMBL319040 | — | — | 1 | 8.39 |
| CHEMBL104021 | — | — | 1 | 8.38 |
| CHEMBL105535 | — | — | 1 | 8.20 |
| CHEMBL322619 | — | — | 1 | 8.05 |
| CHEMBL316978 | — | — | 1 | 7.80 |
| CHEMBL105422 | — | — | 1 | 7.80 |
| CHEMBL104722 | — | — | 1 | 7.70 |
| CHEMBL102504 | — | — | 1 | 7.52 |
| CHEMBL105142 | — | — | 1 | 7.28 |
| CHEMBL102441 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323090 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL105311 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL102798 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL104022 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL102438 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL102785 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL421029 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL106016 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL407443 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL104599 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL420656 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL320442 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL105279 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL319040 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL104021 | — | IC50 | = | 4.22 | nM | 8.38 |
| CHEMBL105535 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL322619 | — | IC50 | = | 8.82 | nM | 8.05 |
| CHEMBL316978 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL105422 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL104722 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL102504 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL105142 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL102441 | — | IC50 | = | 1810.0 | nM | 5.74 |