Assay Detail
Functional
CHEMBL716618
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Compound was tested for inhibition of MOLT-4 cell growth using human lymphoblast cytotoxicity assay in the absence of 2''-deoxy guanosine, cytotoxicity determined by monitoring uptake of [3H]thymidine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.43 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31882 | DEZAGUANINE | 2.0 | 1 | 5.43 |
| CHEMBL61868 | — | — | 1 | - |
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31882 | DEZAGUANINE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL61868 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8040 | 8-AMINOGUANINE | IC50 | > | 500000.0 | nM | - |