Assay Detail
Binding
CHEMBL716780
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Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.01 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158758 | — | — | 1 | 8.49 |
| CHEMBL158555 | — | — | 1 | 8.48 |
| CHEMBL162534 | — | — | 1 | 8.42 |
| CHEMBL159092 | — | — | 1 | 8.41 |
| CHEMBL159035 | — | — | 1 | 8.40 |
| CHEMBL157589 | — | — | 1 | 8.39 |
| CHEMBL162356 | — | — | 1 | 8.37 |
| CHEMBL159217 | — | — | 1 | 8.29 |
| CHEMBL161152 | — | — | 1 | 8.29 |
| CHEMBL422699 | — | — | 1 | 8.24 |
| CHEMBL159068 | — | — | 1 | 8.22 |
| CHEMBL158513 | — | — | 1 | 8.17 |
| CHEMBL158958 | — | — | 1 | 8.17 |
| CHEMBL161255 | — | — | 1 | 8.14 |
| CHEMBL157867 | — | — | 1 | 8.11 |
| CHEMBL161213 | — | — | 1 | 8.10 |
| CHEMBL304237 | — | — | 1 | 8.10 |
| CHEMBL436610 | — | — | 1 | 8.03 |
| CHEMBL161212 | — | — | 1 | 8.03 |
| CHEMBL158904 | — | — | 1 | 8.03 |
| CHEMBL160444 | — | — | 1 | 7.92 |
| CHEMBL423780 | — | — | 1 | 7.92 |
| CHEMBL58615 | — | — | 1 | 7.92 |
| CHEMBL160445 | — | — | 1 | 7.89 |
| CHEMBL345813 | — | — | 1 | 7.85 |
| CHEMBL60402 | — | — | 1 | 7.80 |
| CHEMBL352166 | — | — | 1 | 7.77 |
| CHEMBL346042 | — | — | 1 | 7.68 |
| CHEMBL424342 | — | — | 1 | 7.68 |
| CHEMBL347809 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158758 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL158555 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL162534 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL159092 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL159035 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL157589 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL162356 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL159217 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL161152 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL422699 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL159068 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL158513 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL158958 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL161255 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL157867 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL161213 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL304237 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL158904 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL161212 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL436610 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL160444 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL423780 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL58615 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL160445 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL345813 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL60402 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL352166 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL424342 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL346042 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL347809 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL158642 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL346109 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL159207 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL158051 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL161347 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL345835 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL161300 | — | IC50 | < | 3.0 | nM | - |