Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL716816

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against matrix metalloprotease-11.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Stromelysin-3 (CHEMBL3412)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study.
Vassiliou S, Mucha A, Cuniasse P, Georgiadis D, Lucet-Levannier K, Beau F, Kannan R, Murphy G, Knäuper V, Rio MC, Basset P, Yiotakis A, Dive V.
J Med Chem (1999) 42 : 2610 -2620
PubMed 10411481 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 7.77 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89057 1 9.05
CHEMBL313472 1 8.82
CHEMBL277792 1 8.70
CHEMBL315843 1 8.42
CHEMBL313896 1 8.38
CHEMBL315046 1 8.30
CHEMBL328886 1 8.30
CHEMBL87159 1 8.30
CHEMBL88188 1 8.22
CHEMBL313360 1 8.10
CHEMBL315901 1 8.06
CHEMBL405651 1 8.00
CHEMBL88187 1 7.92
CHEMBL87300 1 7.82
CHEMBL86390 1 7.80
CHEMBL316200 1 7.70
CHEMBL85744 1 7.66
CHEMBL87786 1 7.57
CHEMBL327641 1 7.48
CHEMBL432770 1 7.47
CHEMBL90622 1 7.44
CHEMBL407540 1 7.29
CHEMBL313386 1 7.13
CHEMBL327617 1 7.00
CHEMBL329651 1 6.76
CHEMBL330731 1 6.46
CHEMBL315900 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89057 Ki = 0.9 nM 9.05
CHEMBL313472 Ki = 1.5 nM 8.82
CHEMBL277792 Ki = 2.0 nM 8.70
CHEMBL315843 Ki = 3.8 nM 8.42
CHEMBL313896 Ki = 4.2 nM 8.38
CHEMBL315046 Ki = 5.0 nM 8.30
CHEMBL328886 Ki = 5.0 nM 8.30
CHEMBL87159 Ki = 5.0 nM 8.30
CHEMBL88188 Ki = 6.0 nM 8.22
CHEMBL313360 Ki = 8.0 nM 8.10
CHEMBL315901 Ki = 8.8 nM 8.06
CHEMBL405651 Ki = 10.0 nM 8.00
CHEMBL88187 Ki = 12.0 nM 7.92
CHEMBL87300 Ki = 15.0 nM 7.82
CHEMBL86390 Ki = 16.0 nM 7.80
CHEMBL316200 Ki = 20.0 nM 7.70
CHEMBL85744 Ki = 22.0 nM 7.66
CHEMBL87786 Ki = 27.0 nM 7.57
CHEMBL327641 Ki = 33.0 nM 7.48
CHEMBL432770 Ki = 34.0 nM 7.47
CHEMBL90622 Ki = 36.0 nM 7.44
CHEMBL407540 Ki = 51.0 nM 7.29
CHEMBL313386 Ki = 74.0 nM 7.13
CHEMBL327617 Ki = 100.0 nM 7.00
CHEMBL329651 Ki = 175.0 nM 6.76
CHEMBL330731 Ki = 350.0 nM 6.46
CHEMBL315900 Ki = 2670.0 nM 5.57