Assay Detail
Binding
CHEMBL717012
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Inhibition of matrix metalloprotease-13 (MMP-13)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.01 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90978 | — | — | 1 | 8.89 |
| CHEMBL327621 | — | — | 1 | 8.66 |
| CHEMBL327442 | — | — | 1 | 8.34 |
| CHEMBL539787 | — | — | 1 | 8.29 |
| CHEMBL329558 | — | — | 1 | 8.21 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.09 |
| CHEMBL310649 | — | — | 1 | 7.98 |
| CHEMBL328255 | — | — | 1 | 7.96 |
| CHEMBL88559 | — | — | 1 | 7.80 |
| CHEMBL313168 | — | — | 1 | 7.77 |
| CHEMBL310655 | — | — | 1 | 7.58 |
| CHEMBL538028 | — | — | 1 | 7.34 |
| CHEMBL419868 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90978 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL327621 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL327442 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL539787 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL329558 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL310649 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL328255 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL88559 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL313168 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL310655 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL538028 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL419868 | — | IC50 | = | 65.0 | nM | 7.19 |