Assay Detail
Binding
CHEMBL717024
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Inhibitory activity against matrix metalloprotease-13
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.74 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 8.52 |
| CHEMBL311840 | — | — | 1 | 8.37 |
| CHEMBL308277 | — | — | 1 | 8.35 |
| CHEMBL77995 | — | — | 1 | 8.15 |
| CHEMBL77630 | — | — | 1 | 8.11 |
| CHEMBL77923 | — | — | 1 | 8.11 |
| CHEMBL77163 | — | — | 1 | 8.08 |
| CHEMBL77972 | — | — | 1 | 8.03 |
| CHEMBL77946 | — | — | 1 | 8.00 |
| CHEMBL77667 | — | — | 1 | 7.96 |
| CHEMBL77567 | — | — | 1 | 7.89 |
| CHEMBL77128 | — | — | 1 | 7.89 |
| CHEMBL307494 | — | — | 1 | 7.77 |
| CHEMBL310270 | — | — | 1 | 7.75 |
| CHEMBL445894 | — | — | 1 | 7.72 |
| CHEMBL290377 | — | — | 1 | 7.68 |
| CHEMBL78031 | — | — | 1 | 7.62 |
| CHEMBL78066 | — | — | 1 | 7.54 |
| CHEMBL307168 | — | — | 1 | 7.52 |
| CHEMBL77666 | — | — | 1 | 7.51 |
| CHEMBL308523 | — | — | 1 | 7.43 |
| CHEMBL78102 | — | — | 1 | 7.37 |
| CHEMBL74954 | — | — | 1 | 7.36 |
| CHEMBL420758 | — | — | 1 | 7.27 |
| CHEMBL78111 | — | — | 1 | 7.24 |
| CHEMBL431570 | — | — | 1 | 7.16 |
| CHEMBL78233 | — | — | 1 | 6.68 |
| CHEMBL78027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL311840 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL308277 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL77995 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL77630 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL77923 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL77163 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL77972 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL77946 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL77667 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL77567 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL77128 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL307494 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL310270 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL445894 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL290377 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL78031 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL78066 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL307168 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL77666 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL308523 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL78102 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL74954 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL420758 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL78111 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL431570 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL78233 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL78027 | — | IC50 | > | 300.0 | nM | - |