Assay Detail
Binding
CHEMBL717026
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Inhibitory activity against matrix metalloprotease 13 (MMP-13).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38180 | — | — | 1 | 9.00 |
| CHEMBL287820 | — | — | 1 | 9.00 |
| CHEMBL287871 | — | — | 1 | 9.00 |
| CHEMBL34808 | — | — | 1 | 9.00 |
| CHEMBL38352 | — | — | 1 | 9.00 |
| CHEMBL286848 | — | — | 1 | 9.00 |
| CHEMBL34411 | — | — | 1 | 9.00 |
| CHEMBL288670 | — | — | 1 | 8.70 |
| CHEMBL37788 | — | — | 1 | 8.70 |
| CHEMBL37837 | — | — | 1 | 8.70 |
| CHEMBL35433 | — | — | 1 | 8.52 |
| CHEMBL285546 | — | — | 1 | 8.52 |
| CHEMBL35707 | — | — | 1 | 8.52 |
| CHEMBL35606 | — | — | 1 | 8.52 |
| CHEMBL429336 | — | — | 1 | 8.52 |
| CHEMBL290948 | — | — | 1 | 8.40 |
| CHEMBL290952 | — | — | 1 | 8.40 |
| CHEMBL38106 | — | — | 1 | 8.30 |
| CHEMBL36191 | — | — | 1 | 8.22 |
| CHEMBL287823 | — | — | 1 | 8.15 |
| CHEMBL36021 | — | — | 1 | 8.15 |
| CHEMBL418053 | — | — | 1 | 8.15 |
| CHEMBL36999 | — | — | 1 | 8.05 |
| CHEMBL288671 | — | — | 1 | 8.05 |
| CHEMBL34418 | — | — | 1 | 8.00 |
| CHEMBL34660 | — | — | 1 | 7.80 |
| CHEMBL33980 | — | — | 1 | 7.70 |
| CHEMBL289411 | — | — | 1 | 7.58 |
| CHEMBL35989 | — | — | 1 | 7.57 |
| CHEMBL417144 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38180 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL34411 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL286848 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL38352 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL34808 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL287871 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL287820 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL288670 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL37788 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL37837 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL35433 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL285546 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL35707 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL35606 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL429336 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL290948 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL290952 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL38106 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL36191 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL287823 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL36021 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL418053 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL36999 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL288671 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL34418 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL34660 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL33980 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL289411 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL35989 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL417144 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL289604 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL289222 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL36309 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL35059 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL34666 | — | IC50 | > | 1000.0 | nM | - |