Assay Detail
Functional
CHEMBL717246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 3 (CHEMBL3067) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.12 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40086 | — | — | 1 | 5.77 |
| CHEMBL544508 | — | — | 1 | 5.17 |
| CHEMBL543811 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40086 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL544508 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL543811 | — | EC50 | = | 37000.0 | nM | 4.43 |