Assay Detail
Functional
CHEMBL717322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity evaluated at melanocortin 1 receptor (MC1R) of mouse HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.11 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.22 |
| CHEMBL264190 | — | — | 1 | 7.70 |
| CHEMBL343094 | — | — | 1 | 6.77 |
| CHEMBL138212 | — | — | 1 | 6.30 |
| CHEMBL138771 | — | — | 1 | 6.11 |
| CHEMBL140847 | — | — | 1 | 5.77 |
| CHEMBL141497 | — | — | 1 | 5.18 |
| CHEMBL138100 | — | — | 1 | 5.12 |
| CHEMBL140324 | — | — | 1 | 4.57 |
| CHEMBL138356 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL264190 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL343094 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL138212 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL138771 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL140847 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL141497 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL138100 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL140324 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL138356 | — | EC50 | = | 48000.0 | nM | 4.32 |