Assay Detail
Functional
CHEMBL717325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against mouse Melanocortin 1 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.09 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216295 | — | — | 1 | 10.70 |
| CHEMBL269274 | — | — | 1 | 9.80 |
| CHEMBL2369484 | — | — | 1 | 9.68 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.42 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.26 |
| CHEMBL2369485 | — | — | 1 | 7.22 |
| CHEMBL2370695 | — | — | 1 | 5.76 |
| CHEMBL406550 | — | — | 1 | 5.31 |
| CHEMBL409190 | — | — | 1 | 5.29 |
| CHEMBL410091 | — | — | 1 | 5.21 |
| CHEMBL2371699 | — | — | 1 | 4.88 |
| CHEMBL413465 | — | — | 1 | 4.87 |
| CHEMBL440633 | — | — | 1 | 4.71 |
| CHEMBL266288 | — | — | 1 | - |
| CHEMBL428134 | — | — | 1 | - |
| CHEMBL2369483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216295 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL269274 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2369484 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL2369485 | — | EC50 | = | 59.5 | nM | 7.22 |
| CHEMBL2370695 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL406550 | — | EC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL409190 | — | EC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL410091 | — | EC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL2371699 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL413465 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL440633 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL266288 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL428134 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2369483 | — | EC50 | > | 100000.0 | nM | - |