Assay Detail
Binding
CHEMBL717335
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Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.19 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 6.70 |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | 5.22 |
| CHEMBL34453 | — | — | 1 | 4.66 |
| CHEMBL442347 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL34453 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL442347 | — | EC50 | = | 68000.0 | nM | 4.17 |