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Assay Detail

CHEMBL717437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against matrix metalloprotease-13 (MMP-13)
ChEMBL ↗
44
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Collagenase 3 (CHEMBL280) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Reiter LA, Robinson RP, McClure KF, Jones CS, Reese MR, Mitchell PG, Otterness IG, Bliven ML, Liras J, Cortina SR, Donahue KM, Eskra JD, Griffiths RJ, Lame ME, Lopez-Anaya A, Martinelli GJ, McGahee SM, Yocum SA, Lopresti-Morrow LL, Tobiassen LM, Vaughn-Bowser ML.
Bioorg Med Chem Lett (2004) 14 : 3389 -3395
PubMed 15177439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 8.54 9.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2111753 — — 2 9.46
CHEMBL326369 — — 1 9.43
CHEMBL4524116 — — 1 9.30
CHEMBL115283 — — 1 9.28
CHEMBL432834 — — 1 9.25
CHEMBL325678 — — 1 9.19
CHEMBL4524115 — — 1 9.19
CHEMBL111856 — — 1 9.12
CHEMBL116219 — — 1 9.11
CHEMBL114906 — — 1 9.06
CHEMBL114815 — — 1 9.05
CHEMBL323612 — — 1 9.05
CHEMBL324806 — — 1 9.03
CHEMBL114884 — — 1 9.03
CHEMBL116287 — — 1 9.01
CHEMBL321257 — — 1 8.92
CHEMBL2111754 — — 1 8.92
CHEMBL114831 — — 1 8.89
CHEMBL116237 — — 1 8.82
CHEMBL112470 — — 1 8.82
CHEMBL114148 — — 1 8.82
CHEMBL114272 — — 1 8.77
CHEMBL117375 — — 1 8.77
CHEMBL112609 — — 1 8.70
CHEMBL4524117 — — 1 8.48
CHEMBL113778 — — 1 8.36
CHEMBL112374 — — 1 8.34
CHEMBL116067 — — 1 8.34
CHEMBL325903 — — 1 8.30
CHEMBL114158 — — 1 8.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2111753 — IC50 = 0.35 nM 9.46
CHEMBL326369 — IC50 = 0.37 nM 9.43
CHEMBL4524116 — IC50 = 0.5 nM 9.30
CHEMBL115283 — IC50 = 0.53 nM 9.28
CHEMBL432834 — IC50 = 0.56 nM 9.25
CHEMBL325678 — IC50 = 0.65 nM 9.19
CHEMBL4524115 — IC50 = 0.65 nM 9.19
CHEMBL111856 — IC50 = 0.75 nM 9.12
CHEMBL116219 — IC50 = 0.77 nM 9.11
CHEMBL114906 — IC50 = 0.87 nM 9.06
CHEMBL323612 — IC50 = 0.9 nM 9.05
CHEMBL114815 — IC50 = 0.9 nM 9.05
CHEMBL324806 — IC50 = 0.93 nM 9.03
CHEMBL114884 — IC50 = 0.93 nM 9.03
CHEMBL116287 — IC50 = 0.97 nM 9.01
CHEMBL2111753 — IC50 = 1.0 nM 9.00
CHEMBL2111754 — IC50 = 1.2 nM 8.92
CHEMBL321257 — IC50 = 1.2 nM 8.92
CHEMBL114831 — IC50 = 1.3 nM 8.89
CHEMBL116237 — IC50 = 1.5 nM 8.82
CHEMBL112470 — IC50 = 1.5 nM 8.82
CHEMBL114148 — IC50 = 1.5 nM 8.82
CHEMBL114272 — IC50 = 1.7 nM 8.77
CHEMBL117375 — IC50 = 1.7 nM 8.77
CHEMBL112609 — IC50 = 2.0 nM 8.70
CHEMBL4524117 — IC50 = 3.3 nM 8.48
CHEMBL113778 — IC50 = 4.4 nM 8.36
CHEMBL116067 — IC50 = 4.6 nM 8.34
CHEMBL112374 — IC50 = 4.6 nM 8.34
CHEMBL325903 — IC50 = 5.0 nM 8.30
CHEMBL114158 — IC50 = 5.7 nM 8.24
CHEMBL324615 — IC50 = 6.5 nM 8.19
CHEMBL115168 — IC50 = 9.7 nM 8.01
CHEMBL114528 — IC50 = 11.0 nM 7.96
CHEMBL115666 — IC50 = 13.0 nM 7.89
CHEMBL113705 — IC50 = 14.0 nM 7.85
CHEMBL114378 — IC50 = 17.0 nM 7.77
CHEMBL514138 CGS-27023A IC50 = 18.0 nM 7.75
CHEMBL115877 — IC50 = 19.0 nM 7.72
CHEMBL324578 — IC50 = 24.0 nM 7.62
CHEMBL115223 — IC50 = 25.0 nM 7.60
CHEMBL116904 — IC50 = 49.0 nM 7.31
CHEMBL116348 — IC50 = 50.0 nM 7.30
CHEMBL324555 — IC50 = 210.0 nM 6.68