Assay Detail
Binding
CHEMBL717495
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Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.75 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20154 | — | — | 1 | 9.42 |
| CHEMBL154044 | — | — | 1 | 9.00 |
| CHEMBL156830 | — | — | 1 | 7.96 |
| CHEMBL345447 | — | — | 1 | 7.47 |
| CHEMBL443818 | — | — | 1 | 7.39 |
| CHEMBL154551 | — | — | 1 | 7.21 |
| CHEMBL356413 | — | — | 1 | 7.07 |
| CHEMBL347673 | — | — | 1 | 7.00 |
| CHEMBL348878 | — | — | 1 | 6.68 |
| CHEMBL154440 | — | — | 1 | 6.51 |
| CHEMBL152277 | — | — | 1 | 6.47 |
| CHEMBL436230 | — | — | 1 | 6.38 |
| CHEMBL154040 | — | — | 1 | 6.04 |
| CHEMBL153882 | — | — | 1 | 5.89 |
| CHEMBL345306 | — | — | 1 | 5.77 |
| CHEMBL117225 | — | — | 1 | 5.75 |
| CHEMBL154169 | — | — | 1 | 5.17 |
| CHEMBL345305 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20154 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL154044 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL156830 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL345447 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL443818 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL154551 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL356413 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL347673 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL348878 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL154440 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL152277 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL436230 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL154040 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL153882 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL345306 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL117225 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL154169 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL345305 | — | IC50 | = | 52000.0 | nM | 4.28 |