Assay Detail
Functional
CHEMBL717600
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Effective concentration against mouse melanocortin MC4 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.81 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216295 | — | — | 1 | 10.06 |
| CHEMBL2369484 | — | — | 1 | 9.74 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.68 |
| CHEMBL269274 | — | — | 1 | 8.85 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 8.27 |
| CHEMBL266288 | — | — | 1 | 8.03 |
| CHEMBL2369485 | — | — | 1 | 7.24 |
| CHEMBL406550 | — | — | 1 | 6.35 |
| CHEMBL410091 | — | — | 1 | 4.96 |
| CHEMBL440633 | — | — | 1 | 4.87 |
| CHEMBL2371699 | — | — | 1 | - |
| CHEMBL2369483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216295 | — | EC50 | = | 0.087 | nM | 10.06 |
| CHEMBL2369484 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL269274 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL266288 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2369485 | — | EC50 | = | 57.1 | nM | 7.24 |
| CHEMBL406550 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL410091 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL440633 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2371699 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2369483 | — | EC50 | > | 100000.0 | nM | - |