Assay Detail
Binding
CHEMBL718136
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50% inhibition of human recombinant Matrilysin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.09 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 8.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.70 |
| CHEMBL264495 | — | — | 1 | 7.70 |
| CHEMBL291994 | — | — | 1 | 6.30 |
| CHEMBL292313 | — | — | 1 | 6.30 |
| CHEMBL294066 | — | — | 1 | 6.00 |
| CHEMBL58945 | — | — | 1 | 5.70 |
| CHEMBL60546 | — | — | 1 | 5.70 |
| CHEMBL303756 | — | — | 1 | 5.70 |
| CHEMBL62245 | — | — | 1 | 5.70 |
| CHEMBL62056 | — | — | 1 | 5.52 |
| CHEMBL59248 | — | — | 1 | 5.30 |
| CHEMBL293382 | — | — | 1 | 5.00 |
| CHEMBL418472 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL264495 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL291994 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL292313 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL294066 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL58945 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL60546 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL303756 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL62245 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL62056 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL59248 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL293382 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL418472 | — | IC50 | = | 40000.0 | nM | 4.40 |