Assay Detail
Binding
CHEMBL718141
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Inhibitory activity against the Matrix Metalloprotease-8
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 68 | 8.09 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293503 | — | — | 1 | 10.00 |
| CHEMBL293357 | — | — | 1 | 9.30 |
| CHEMBL54054 | — | — | 1 | 9.15 |
| CHEMBL439931 | — | — | 1 | 9.15 |
| CHEMBL56498 | — | — | 1 | 9.00 |
| CHEMBL54483 | — | — | 1 | 8.96 |
| CHEMBL293528 | — | — | 1 | 8.92 |
| CHEMBL55522 | — | — | 1 | 8.89 |
| CHEMBL54904 | — | — | 1 | 8.89 |
| CHEMBL55984 | — | — | 1 | 8.85 |
| CHEMBL55521 | — | — | 1 | 8.82 |
| CHEMBL54535 | — | — | 1 | 8.82 |
| CHEMBL301085 | — | — | 1 | 8.70 |
| CHEMBL53847 | — | — | 1 | 8.68 |
| CHEMBL55110 | — | — | 1 | 8.62 |
| CHEMBL54436 | — | — | 1 | 8.62 |
| CHEMBL56025 | — | — | 1 | 8.48 |
| CHEMBL54621 | — | — | 1 | 8.40 |
| CHEMBL300362 | — | — | 1 | 8.40 |
| CHEMBL297488 | — | — | 1 | 8.30 |
| CHEMBL300807 | — | — | 1 | 8.30 |
| CHEMBL54915 | — | — | 1 | 8.30 |
| CHEMBL299600 | — | — | 1 | 8.22 |
| CHEMBL52531 | — | — | 1 | 8.22 |
| CHEMBL301977 | — | — | 1 | 8.15 |
| CHEMBL298606 | — | — | 1 | 8.15 |
| CHEMBL54965 | — | — | 1 | 8.10 |
| CHEMBL292431 | — | — | 1 | 8.10 |
| CHEMBL54697 | — | — | 1 | 8.05 |
| CHEMBL55154 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293503 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL293357 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL439931 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL54054 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL56498 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL54483 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL293528 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL55522 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL54904 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL55984 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL55521 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL54535 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL301085 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL53847 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL54436 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL55110 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL56025 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL54621 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL300362 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL297488 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL300807 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL54915 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL299600 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL52531 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL298606 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL301977 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL54965 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL292431 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL54697 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL55154 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL54617 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL417200 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL53044 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL293305 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL298822 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL56065 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL55744 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL301786 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL53051 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL299023 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL51862 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL280017 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL54981 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL53457 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL55907 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL53094 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL417757 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL56951 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL293774 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL52532 | — | Ki | = | 22.0 | nM | 7.66 |