Assay Detail
Functional
CHEMBL718155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.99 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177258 | — | — | 1 | 7.18 |
| CHEMBL369705 | — | — | 1 | 7.16 |
| CHEMBL173949 | — | — | 1 | 7.04 |
| CHEMBL177238 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177258 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL369705 | — | EC50 | = | 68.7 | nM | 7.16 |
| CHEMBL173949 | — | EC50 | = | 91.7 | nM | 7.04 |
| CHEMBL177238 | — | EC50 | = | 277.0 | nM | 6.56 |